METHODS FOR DRUG DISCOVERY - DEVELOPMENT OF POTENT, SELECTIVE, ORALLY EFFECTIVE CHOLECYSTOKININ ANTAGONISTS

被引：1325

作者：

EVANS, BE ^{[1
]}

RITTLE, KE ^{[1
]}

BOCK, MG ^{[1
]}

DIPARDO, RM ^{[1
]}

FREIDINGER, RM ^{[1
]}

WHITTER, WL ^{[1
]}

LUNDELL, GF ^{[1
]}

VEBER, DF ^{[1
]}

ANDERSON, PS ^{[1
]}

CHANG, RSL ^{[1
]}

LOTTI, VJ ^{[1
]}

CERINO, DJ ^{[1
]}

CHEN, TB ^{[1
]}

KLING, PJ ^{[1
]}

KUNKEL, KA ^{[1
]}

SPRINGER, JP ^{[1
]}

HIRSHFIELD, J ^{[1
]}

机构：

[1] MERCK INST THERAPEUT RES,RAHWAY,NJ 07065

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 12期

关键词：

D O I：

10.1021/jm00120a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2235 / 2246

页数：12

共 56 条

[1] DIAZEPAM-BINDING INHIBITOR - A NEUROPEPTIDE LOCATED IN SELECTED NEURONAL POPULATIONS OF RAT-BRAIN [J].

ALHO, H ;

COSTA, E ;

FERRERO, P ;

FUJIMOTO, M ;

COSENZAMURPHY, D ;

GUIDOTTI, A .

SCIENCE, 1985, 229 (4709) :179-182

[2] THE CHOLECYSTOKININ ANTAGONIST L-364,718 INHIBITS THE ACTION OF CHOLECYSTOKININ BUT NOT BOMBESIN ON RAT PANCREATIC-SECRETION INVIVO [J].

ANDERSON, L ;

DOCKRAY, GJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 146 (2-3) :307-311

[3]

ARIENS EJ, 1979, RECEPTORS COMPREHENS, V1, P33

[4] A REARRANGEMENT OF 5-ARYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-14-OXIDES [J].

BELL, SC ;

CHILDRESS, SJ .

JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (05) :1691-&

[5]

BELL SC, 1964, J HETEROCYCL CHEM, V4, P647

[6]

BELL SC, 1965, Patent No. 3198789

[7]

BLOUNT JF, 1983, MOL PHARM, V24, P426

[8] AN EXPEDIENT SYNTHESIS OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

VEBER, DF ;

FREIDINGER, RM .

TETRAHEDRON LETTERS, 1987, 28 (09) :939-942

[9] SYNTHESIS AND RESOLUTION OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES [J].

BOCK, MG ;

DIPARDO, RM ;

EVANS, BE ;

RITTLE, KE ;

VEBER, DF ;

FREIDINGER, RM ;

HIRSHFIELD, J ;

SPRINGER, JP .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3232-3239

[10] BENZODIAZEPINES ANTAGONIZE CHOLECYSTOKININ-INDUCED ACTIVATION OF RAT HIPPOCAMPAL-NEURONS [J].

BRADWEJN, J ;

DEMONTIGNY, C .

NATURE, 1984, 312 (5992) :363-364

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