SPECIFIC ANTIBODY-DEPENDENT ACTIVATION OF NEUTROPHILS BY LIPOSOMES CONTAINING SPIN-LABEL LIPID HAPTENS

被引：22

作者：

HAFEMAN, DG

PARCE, JW

MCCONNELL, HM

机构：

[1] Stauffer Laboratory for Physical Chemistry Stanford University, Stanford

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91745-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superoxide production by human neutrophils can be stimulated by liposomal membranes containing nitroxide spin-labeled lipids in the presence of specific rabbit antibodies [Ab] directed against the nitroxide group. The extent of superoxide production depended strongly on lipid composition under conditions where the concentration of Ab and number of exposed haptens were maintained constant. The dependence of neutrophil activation on the physical properties of the liposomal lipid membrane appears similar to the dependence of complement depletion on these physical properties.

引用

页码：522 / 528

页数：7

共 24 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].