TRANSFORMING GROWTH-FACTOR-BETA EFFECTS ON EXPRESSION OF G(1) CYCLINS AND CYCLIN-DEPENDENT PROTEIN-KINASES

被引：290

作者：

GENG, Y ^{[1
]}

WEINBERG, RA ^{[1
]}

机构：

[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 21期

关键词：

CELL CYCLE PROGRESSION;

D O I：

10.1073/pnas.90.21.10315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor beta1 (TGF-beta1) is a potent growth-inhibitory polypeptide. The mechanism of TGF-beta1 inhibition has been related to its ability to prevent the hyperphosphorylation of retinoblastoma protein (pRb). Several lines of evidence have suggested that cell cycle-regulated protein kinases are responsible for the hyperphosphorylation of pRb. We demonstrate here that TGF-beta1 has profound effects on the expression of genes encoding certain G1 cyclins and their associated kinases, which provides one explanation of TGF-beta1 effects on pRb hyperphosphorylation. These results also suggest that the growth-inhibitory effects of TGF-beta1 in many cells are attributable to its effects on the cell cycle apparatus involved in programming G1 transit.

引用

页码：10315 / 10319

页数：5

共 35 条

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