Chronic Cholestatic Liver Injury Attributable to Vedolizumab

被引：14

作者：

Stine, Jonathan G. ^{[1
]}

Wang, Jennifer ^{[2
]}

Behm, Brian W. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Div Gastroenterol & Hepatol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA

来源：

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2016年 / 4卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Hepatotoxicity; Integrin inhibitor; Primary sclerosing cholangitis; Inflammatory bowel disease;

D O I：

10.14218/JCTH.2016.00018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Drug-induced liver injury is a rare but clinically important diagnosis. Vedolizumab is an alpha 4 beta 7 integrin inhibitor recently approved for use in patients with moderate-to-severe inflammatory bowel disease. Cases of hepatoxicity due to vedolizumab in the pre-marketing stage were rare, and all cases resolved upon drug withdrawal. We present here the first reported case of hepatotoxicity attributable to vedolizumab, which despite drug cessation persisted with chronic cholestatic liver injury. (C) 2016 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Inc. All rights reserved.

引用

页码：277 / 280

页数：4

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