Mindfulness-based stress reduction (MBSR) originated from Buddhist spiritual practices with the aim of restoring wholeness and well-being among medical patients suffering from pain and illness. MBSR effectively reduces a wide range of symptoms, but investigations measuring positive outcomes tend to include only nonclinical or nondistressed individuals. In the current study, 30 participants seeking psychological services reported significant reductions on symptom measures at their final MBSR session, accompanied by increased mindfulness, personal growth, life satisfaction, and improved quality of life. The spiritual origins of MBSR may reflect its potential to enhance personal growth and quality of life beyond mere symptom reduction.