VENTILATORY RESPONSE TO CO2 AND HYPOXIA DURING COLD-EXPOSURE IN AWAKE RATS

Recently, we have described the effects of hypoxia and of hypercapnia on the metabolic (V-O2) and ventilatory responses to cold in unanesthetized intact and carotid body-denervated (CBD) rats (Gautier et al., J. Appl. Physiol. 73: 847-854, 1992 and 75: 2570-2579, 1993). In the present paper, we have reanalyzed the above results for a more detailed study of the interactions of hypoxia (FIO2 = 0.12), hypercapnia (FICO2 = 0.04) and changes in V-O2 with the ventilatory control. The results show that: (1) Compared to normoxia, in hypoxia increments in V and VT are proportional to V-O2 whereas in hypercapnia increments in ventilation (V) and tidal volume (VT) are independent of V-O2. In both hypoxia and hypercapnia, increases in respiratory frequency (fR) are independent of V-O2; and (2) Interactions of hypoxia, hypercapnia and V-O2 with control of V persist in CBD rats but, for a given V-O2, V, VT and fR are lower than in intact rats. These interactions are essentially similar to those observed during muscular exercise performed in normoxia, hypoxia or hypercapnia. It is suggested that during cold exposure or muscular exercise, resulting both in increased V-O2, there are common integrative structures probably located in the hypothalamus which are involved in the control of breathing.