PORPHOBILINOGEN DEAMINASE AND ITS STRUCTURAL SIMILARITY TO THE BIDOMAIN BINDING-PROTEINS

被引：24
|
作者：
LOUIE, GV
机构：
[1] Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, London, WC1E 7HX, Malet Street
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0959-440X(05)80113-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The tetrapyrrole-biosynthesis enzyme porphobilinogen deaminase has in two of its domains the same alpha/beta polypeptide-chain fold as the transferrins and the periplasmic binding proteins. These proteins have in common an active-site cleft located at the interface between two domains. The binding proteins and porphobilinogen deaminase are likely related by divergent evolution. The interdomain motions observed in the binding proteins are suggested also to have an important role in the mechanism of the reaction catalyzed by porphobilinogen deaminase.
引用
收藏
页码：401 / 408
页数：8
相关论文
共 50 条
  • [31] EXTRACELLULAR ANDROGEN BINDING-PROTEINS
    BARDIN, CW
    MUSTO, N
    GUNSALUS, G
    KOTITE, N
    CHENG, SL
    LARREA, F
    BECKER, R
    ANNUAL REVIEW OF PHYSIOLOGY, 1981, 43 : 189 - 198
  • [32] PENICILLIN BINDING-PROTEINS OF BACTERIA
    STROMINGER, JL
    BUCHANAN, C
    CURTIS, S
    KOZARICH, JW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1976, : 73 - 73
  • [33] CELLULAR RETINOID BINDING-PROTEINS
    SUNDELIN, J
    ERIKSSON, U
    MELHUS, H
    NILSSON, M
    LUNDVALL, J
    BAVIK, CO
    HANSSON, E
    LAURENT, B
    PETERSON, PA
    CHEMISTRY AND PHYSICS OF LIPIDS, 1985, 38 (1-2) : 175 - 185
  • [34] IGF BINDING-PROTEINS AND THEIR FUNCTIONS
    CLEMMONS, DR
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 1993, 35 (04) : 368 - 375
  • [35] UTERINE PROSTAGLANDIN BINDING-PROTEINS
    KIMBLE, FA
    PROSTAGLANDINS, 1974, 6 (06): : 541 - 541
  • [36] INTRACELLULAR BINDING-PROTEINS FOR THALIDOMIDE
    HULLIN, R
    VOGELSANG, GB
    BRUNDRETTE, R
    COLVIN, OM
    SANTOS, GW
    HESS, AD
    EXPERIMENTAL HEMATOLOGY, 1987, 15 (05) : 476 - 476
  • [37] ASSAYS FOR IGF BINDING-PROTEINS
    RUTANEN, EM
    PEKONEN, F
    ACTA ENDOCRINOLOGICA, 1991, 124 : 70 - 73
  • [38] DNA BINDING-PROTEINS OF YEAST
    FINKELSTEIN, DB
    BUTOW, RA
    FEDERATION PROCEEDINGS, 1975, 34 (03) : 587 - 587
  • [39] RHYNCHOSPOROSIDE BINDING-PROTEINS OF BARLEY
    BELTRAN, JP
    STROBEL, GA
    FEBS LETTERS, 1978, 96 (01): : 34 - 36
  • [40] MODULATOR BINDING-PROTEINS OF TESTIS
    SOBUE, K
    KAKIUCHI, S
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 93 (03) : 850 - 856
12345