CASEIN KINASE II-ALPHA TRANSGENE-INDUCED MURINE LYMPHOMA - RELATION TO THEILERIOSIS IN CATTLE

被引：357

作者：

SELDIN, DC ^{[1
]}

LEDER, P ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT GENET, BOSTON, MA 02115 USA

来源：

SCIENCE | 1995年 / 267卷 / 5199期

关键词：

D O I：

10.1126/science.7846532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c-myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc.

引用

页码：894 / 897

页数：4

共 32 条

[1] THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].

ADAMS, JM ;

HARRIS, AW ;

PINKERT, CA ;

CORCORAN, LM ;

ALEXANDER, WS ;

CORY, S ;

PALMITER, RD ;

BRINSTER, RL .

NATURE, 1985, 318 (6046) :533-538

[2] ONCOGENE COOPERATION IN LYMPHOCYTE-TRANSFORMATION - MALIGNANT CONVERSION OF E-MU-MYC TRANSGENIC PRE-B CELLS-INVITRO IS ENHANCED BY V-H-RAS OR V-RAF BUT NOT V-ABL [J].

ALEXANDER, WS ;

ADAMS, JM ;

CORY, S .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (01) :67-73

[3] CASEIN KINASE-II INHIBITS THE DNA-BINDING ACTIVITY OF MAX HOMODIMERS BUT NOT MYC MAX HETERODIMERS [J].

BERBERICH, SJ ;

COLE, MD .

GENES & DEVELOPMENT, 1992, 6 (02) :166-176

[4]

CARROLL D, 1989, J BIOL CHEM, V264, P7345

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] 2 MESSENGER-RNAS CAN BE PRODUCED FROM A SINGLE IMMUNOGLOBULIN-MU GENE BY ALTERNATIVE RNA PROCESSING PATHWAYS [J].

EARLY, P ;

ROGERS, J ;

DAVIS, M ;

CALAME, K ;

BOND, M ;

WALL, R ;

HOOD, L .

CELL, 1980, 20 (02) :313-319

[7] IDENTIFICATION OF A NOVEL CASEIN KINASE-ACTIVITY IN HELA-CELL NUCLEI [J].

FRIEDRICH, TD ;

INGRAM, VM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 992 (01) :41-48

[8] RECOMBINATIONS OF CHROMOSOMAL BANDS 6P21 AND 14Q24 CHARACTERIZE PULMONARY HAMARTOMAS [J].

JOHANSSON, M ;

DIETRICH, C ;

MANDAHL, N ;

HAMBRAEUS, G ;

JOHANSSON, L ;

CLAUSEN, PP ;

MITELMAN, F ;

HEIM, S .

BRITISH JOURNAL OF CANCER, 1993, 67 (06) :1236-1241

[9] ESTABLISHMENT OF MOUSE-CELL LINES WHICH CONSTITUTIVELY SECRETE LARGE QUANTITIES OF INTERLEUKIN-2, INTERLEUKIN-3, INTERLEUKIN-4 OR INTERLEUKIN-5, USING MODIFIED CDNA EXPRESSION VECTORS [J].

KARASUYAMA, H ;

MELCHERS, F .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (01) :97-104

[10]

KRIEG PA, 1987, METHOD ENZYMOL, V155, P397

← 1 2 3 4 →