A SEARCH FOR LONGITUDINAL VARIATIONS IN TRACE-ELEMENT LEVELS IN NAILS OF ALZHEIMERS-DISEASE PATIENTS

被引：18

作者：

VANCE, DE

EHMANN, WD

MARKESBERY, WR

机构：

[1] UNIV KENTUCKY,DEPT CHEM,LEXINGTON,KY 40506

[2] UNIV KENTUCKY,SANDERS BROWN CTR AGING,LEXINGTON,KY 40506

[3] EASTERN KENTUCKY UNIV,DEPT CHEM,RICHMOND,KY 40475

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1990年 / 26-7卷

关键词：

Alzheimer's disease; bromine; INAA; longitudinal study; mercury; myasthenia gravis; nails; potassium; radiochemical analysis; trace element levels; zinc;

D O I：

10.1007/BF02992701

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Levels of Br, Hg, K, and Zn were determined by INAA in the nails of Alzheimer's disease (AD) patients at 6-mo intervals for up to 3 yr. These elements have been shown to be imbalanced in AD nail. Bromine showed no trends. Mercury tended to decrease in nail with increasing age of patient, and with the duration and severity of the dementia. Potassium and Zn tended to increase with these came factors. Hence, progressive changes in trace-element levels do occur in AD nail, although imbalances are detected even in the earliest sampled stages of the disease. © 1990 Humana Press Inc.

引用

页码：461 / 470

页数：10

共 19 条

[1] BLOOD ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN SENILE DEMENTIA OF ALZHEIMER TYPE [J].