VAB-6 CHEMOTHERAPY CAUSES SPURIOUS ELEVATION OF ALPHA-FETOPROTEIN ASSOCIATED WITH LIVER DYSFUNCTIONS

被引：9

作者：

HIDA, S ^{[1
]}

NISHIMURA, K ^{[1
]}

NISHIO, Y ^{[1
]}

OISHI, K ^{[1
]}

TAKEUCHI, H ^{[1
]}

YOSHIDA, O ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT UROL,54 SHOGOIN KAWAHARA MACHI,SAKYO KU,KYOTO 606,JAPAN

来源：

UROLOGIA INTERNATIONALIS | 1991年 / 46卷 / 01期

关键词：

ALPHA-FETOPROTEIN; FALSE POSITIVE; HEPATIC DYSFUNCTION; VAB-6; CHEMOTHERAPY; TESTICULAR CANCER;

D O I：

10.1159/000281762

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In order to elucidate the mechanism of elevation of alpha-fetoprotein (AFP) which we often observed during VAB-6 chemotherapy, we analyzed sequential changes of AFP, liver enzymes and bilirubin in 10 patients with evaluable disseminated testicular cancer who were treated with VAB-6 chemotherapy. None of the patients had previous liver disease or hepatic involvement. During the early phase of each course of chemotherapy, AFP showed a temporary elevation associated with reversible increase in liver enzymes and bilirubin. These changes returned to normal before the next course of chemotherapy. In each patient, marked tumor regression occurred as a result of VAB-6 chemotherapy. Nine of the 10 patients remain free of disease after treatment. We conclude that during VAB-6 chemotherapy, a temporary elevation of AFP is common, associated with reversible liver dysfunctions, and that this spurious elevation of the tumor marker, most likely caused by a heavy dose of cisplatin, should not be interpreted as related treatment failure.

引用

页码：1 / 5

页数：5