1-CHLOROMETHYLPYRENE - A REFERENCE SKIN SENSITIZER AND GENOTOXIN

被引：12
作者：
ASHBY, J
GALLAGHER, JE
KOHAN, M
TINWELL, H
KIMBER, I
PATON, D
CALLANDER, RD
CHOUROULINKOV, I
机构：
[1] CTR NATL RECH SCI CANC,F-94802 VILLEJUIF,FRANCE
[2] US EPA,RES TRIANGLE PK,NC 27711
来源：
MUTATION RESEARCH | 1990年 / 243卷 / 04期
关键词：
Bone-marrow micronuclei; DNA adducts; I-Chloromethylpyrene; Skin sensitization;
D O I：
10.1016/0165-7992(90)90144-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
1-Chloromethylpyrene (1-CMP) has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from benzo[a]pyrene and 1-nitropyrene. It was mutagenic to Salmonella (> 100 pg/plate) an exceptionally reactive to DNA when assessed by the 32P-postlabelling technique. 1-CMP was inactive in a mouse bone micronucleus assay when administered by gavage, probably due to hydrolysis, whose kinetics have been studied (t 1 2 ∼ 23 min at 37°C). However, as expected, it was a potent skin toxin as determined by its activity as a mitogen to mouse skin and its contact allergenicity, as determined using the local lymph node proliferative assay. It is concluded that 1-CMP will probably be a potent human skin carcinogen and contact allergen. © 1990.
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页码：281 / 289
页数：9
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