THE CPG ISLAND IN THE 5'-REGION OF THE G6PD GENE OF MAN AND MOUSE

被引：40

作者：

TONIOLO, D ^{[1
]}

FILIPPI, M ^{[1
]}

DONO, R ^{[1
]}

LETTIERI, T ^{[1
]}

MARTINI, G ^{[1
]}

机构：

[1] CNR, IST INT GENET & BIOFIS, I-80125 NAPLES, ITALY

来源：

GENE | 1991年 / 102卷 / 02期

关键词：

RECOMBINANT DNA; HUMAN; RODENT; SEQUENCE CONSERVATION; X-CHROMOSOME; DNA METHYLATION;

D O I：

10.1016/0378-1119(91)90078-P

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The nucleotide (nt) sequence of the entire CpG island in the 5' region of the human glucose-6-phosphate dehydrogenase-encoding gene (G6PD) and of the corresponding region in mouse was determined. In comparison to the human gene, the 5' region of the mouse G6PD gene has highly reduced G + C and CpG dinucleotide content, but maintains the functional features of a CpG island, as it is differentially methylated on the active vs. the inactive X chromosome. In addition to the expected conservation of exons, nt sequence comparison showed that several boxes are highly conserved between the two species in the 5' flanking DNA and in the first intron. Moreover, the conservation of the position of most CpG dinucleotides in the promoter region and in one of the upstream boxes, at about -900, gives support to the hypothesis that, in each island, specific CpGs play a major role in the regulation of gene expression.

引用

页码：197 / 203

页数：7

共 18 条

[1] CPG ISLANDS OF THE X-CHROMOSOME ARE GENE ASSOCIATED [J].