METABOLISM IN MICE OF ARSENIC COMPOUNDS CONTAINED IN THE RED ALGA PORPHYRA-YEZOENSIS

被引：11

作者：

SHIOMI, K

CHINO, M

KIKUCHI, T

机构：

[1] Tokyo University of Fisheries, Tokyo, 108, Konan-4, Minato-ku

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 1990年 / 4卷 / 03期

关键词：

Arsenic; arsenosugars; excretion; feces; mice; Porphyra yezoensis; red alga; urine;

D O I：

10.1002/aoc.590040317

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Arsenic compounds in the red alga Porphyra yezoensis were purified by gel filtration on Bio‐Gel P‐2; chromatographic behavior suggested that they were arsenic‐containing ribofuranosides (arsenosugars). When partially purified arsenosugars were orally administered to mice, 86% and 13% of the arsenic administered were excreted in feces and urine, respectively, within 48 h. Arsenic compounds excreted in feces were identified as arsenosugars by gel filtration and highperformance liquid chromatography, while those excreted in urine were identified as methylarsonic acid, dimethylarsinic acid and arsenobetaine. On the other hand, upon intravenous administration of arsenosugars, a large part of the arsenic administered was excreted rapidly in urine; after 72 h, 92% of the arsenic administered was recovered in urine and 6% in feces. Similarly to the case of oral administration, methylarsonic acid, dimethylarsinic acid and arsenobetaine were detected in urine. Copyright © 1990 John Wiley & Sons Ltd.

引用

页码：281 / 286

页数：6

共 18 条

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