COMPLEMENTARY-DNA CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF A HUMAN GENE-RELATED TO THE POLIOVIRUS RECEPTOR-ENCODING GENE

被引：149

作者：

LOPEZ, M

EBERLE, F

MATTEI, MG

GABERT, J

BIRG, F

BARDIN, F

MAROC, C

DUBREUIL, P

机构：

[1] CTR GENET MED,HOP ENFANTS LA TIMONE,INSERM,U242,F-13385 MARSEILLE 5,FRANCE

[2] INST J PAOLI I CALMETTES,F-13273 MARSEILLE,FRANCE

来源：

GENE | 1995年 / 155卷 / 02期

关键词：

MURINE; IMMUNOGLOBULIN SUPERFAMILY; SEQUENCE ALIGNMENT; GENE EXPRESSION;

D O I：

10.1016/0378-1119(94)00842-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11.

引用

页码：261 / 265

页数：5

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