THE HUMAN GLIOMA PATHOGENESIS-RELATED PROTEIN IS STRUCTURALLY RELATED TO PLANT PATHOGENESIS-RELATED PROTEINS AND ITS GENE IS EXPRESSED SPECIFICALLY IN BRAIN-TUMORS

被引：116

作者：

MURPHY, EV

ZHANG, Y

ZHU, WJ

BIGGS, J

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL SURG,SAN FRANCISCO,CA 94143

[2] MCMASTER UNIV,DEPT BIOMED SCI,DIV NEUROSCI,HAMILTON,ON,CANADA

[3] UNIV ALABAMA,CTR COMPREHENS CANC,BIRMINGHAM,AL 35294

来源：

GENE | 1995年 / 159卷 / 01期

关键词：

PLANT DEFENSE-RESPONSE; CDNA; ASTROCYTOMA; GLIOBLASTOMA; IMMUNOLOGY;

D O I：

10.1016/0378-1119(95)00061-A

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, glioblastoma multiforme/astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.

引用

页码：131 / 135

页数：5

共 15 条

[1] COMPARISON OF 3 PATHOGENESIS-RELATED PROTEINS FROM PLANTS OF 2 CULTIVARS OF TOBACCO INFECTED WITH TMV [J].