CHIMANINES, NEW 2-SUBSTITUTED QUINOLINES, ISOLATED FROM AN ANTIPARASITIC PLANT IN BOLIVIA - GALIPEA-LONGIFLORA

被引:78
作者
FOURNET, A
HOCQUEMILLER, R
ROBLOT, F
CAVE, A
RICHOMME, P
BRUNETON, J
机构
[1] FAC PHARM CHATENAY MALABRY,CNRS,PHARMACOGNOSIE LAB,F-92296 CHATENAY MALABRY,FRANCE
[2] CTR ETUD PLANTES MED,UNITE ENSEIGNEMENT & RECH SCI MED & PHARMACEUT,F-49000 ANGERS,FRANCE
来源
JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 09期
关键词
D O I
10.1021/np50099a013
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Petroleum ether and CHCl3 extracts of stem, root bark, and leaves of Galipea longiflora were found active in vitro against Leishmania sp. and Trypanosoma cruzi at 100 mug/ml. The activity-guided fractionation of the extracts by chromatography afforded thirteen active compounds identified as 2-substituted quinoline alkaloids. Four new 2-alkylquinoline alkaloids were isolated and identified from leaves or trunk bark of G. longiflora: 4-methoxy-2-n-propylquinoline [10] (chimanine A), 2-(E)-prop-1'-enylquinoline [11] (chimanine B), 4-methoxy-2-(E)-prop-1'-enylquinoline [12] (chimanine C), and 2-(1',2'-trans-epoxypropyl)-quinoline [13] (chimanine D). These alkaloids are accompanied by eight known 2-substituted quinolines (2-9), and by one known furo-(2,3b)-quinoline alkaloid, skimmianine [1].
引用
收藏
页码:1547 / 1552
页数:6
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