ENUMERATION OF ALLOREACTIVE HELPER LYMPHOCYTES-T WHICH COOPERATE WITH CYTOLYTIC LYMPHOCYTES-T

被引:62
作者
LUTZ, CT
GLASEBROOK, AL
FITCH, FW
机构
关键词
D O I
10.1002/eji.1830110911
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The number of alloreactive [mouse] helper T lymphocytes (HTL) which cooperate with cytolytic T lymphocytes were quantified in a sensitive limit dilution system. Approximately 1 in 330 splenic T lymphocytes developed helper activity in response to alloantigen of a single haplotype. Most HTL appeared to cooperate nonspecifically with the cytolytic cells. A significant number of alloreactive HTL precursors recognized H-2 K or D alloantigen, but roughly 6-fold more HTL precursors responded to H-2 I, and roughly 20-fold more responded to non-H-2, presumably Mls, alloantigen. Alloantigen encoded by the H-2 I and non-H-2 Mls regions probably preferentially stimulate helper T lymphocytes; alloantigens encoded by the H-2 K and D regions probably preferentially stimulate cytolytic T lymphocytes.
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页码:726 / 734
页数:9
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