THE ROLE OF CLATHRIN, ADAPTERS AND DYNAMIN IN ENDOCYTOSIS

被引：313
作者：
ROBINSON, MS
机构：
[1] University of Cambridge, Cambridge
来源：
CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 04期
关键词：
D O I：
10.1016/0955-0674(94)90074-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Clathrin-coated vesicles bud from the plasma membrane and from the trans-Golgi network; both populations of coated vesicles participate in the endocytic pathway. Coated-vesicle formation is initiated by the binding of cytosolic adaptor complexes to putative adaptor receptors on the appropriate membrane. Clathrin then binds to the adaptors and assembles to form a coated bud, which pinches off as a coated vesicle. The GTPase dynamin facilitates the formation of coated vesicles at the plasma membrane through an as yet unknown mechanism. Recent studies suggest that regulatory mechanisms may operate at each of these stages.
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页码：538 / 544
页数：7
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