Role of melatonin in cancer treatment

被引：0

作者：

Escames, Germaine ^{[1
,2
,3
]}

Acuna-Castroviejo, Dario ^{[1
,2
,3
]}

Fernandez-Gila, Beatriz, I ^{[1
]}

Guerra-Libreroa, Ana ^{[1
]}

Floridol, Javier ^{[1
]}

Martinez-Ruiz, Laura ^{[1
]}

Santana, Cesar ^{[1
]}

机构：

[1] Univ Granada, Ctr Invest Biomed, Parque Tecnol Ciencias Salud,Ave Conocimiento S-N, Granada 18100, Spain

[2] Univ Granada, Fac Med, Dept Fisiol, Granada, Spain

[3] Ibs Granada, CIBERFES, Hosp Campus Salud, Granada 18016, Spain

来源：

APPROACHES TO AGING CONTROL | 2018年 / 22期

关键词：

melatonin; cancer; apoptosis; antioxidant; angiogenesis; estrogen signaling pathway; metastasis;

D O I：

暂无

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Melatonin is a natural substance ubiquitous in distribution and present in almost all species ranging from unicellular organisms to humans. Melatonin is synthesized not only in the pineal gland but also in most tissues where it may play a cytoprotective function via paracrine or autocrine effects. Melatonin is effective in suppressing neoplastic growth in a variety of tumors and as an adjuvant therapy, it can be beneficial in treating cancer patients. The aim of this report is to summarize the possible mechanisms involved in melatonin oncostasis and to review what is known about the clinical application in cancer patients.

引用

页码：47 / 61

页数：15

共 50 条

[21] Effects of Melatonin and Doxorubicin on Primary Tumor And Metastasis in Breast Cancer Model
Tanriover, Gamze
Dilmac, Sayra
Aytac, Gunes
Farooqi, Ammad Ahmad
Sindel, Muzaffer
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2022, 22 (10) : 1970 - 1983
[22] The role of melatonin in immuno-enhancement: potential application in cancer
Miller, SC
Pandi, PSR
Esquifino, AI
Cardinali, DP
Maestroni, GJM
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2006, 87 (02) : 81 - 87
[23] Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved
Bastani, Sepideh
Akbarzadeh, Moloud
Rastgar Rezaei, Yeganeh
Farzane, Ali
Nouri, Mohammad
Mollapour Sisakht, Mahsa
Fattahi, Amir
Akbarzadeh, Maryam
Reiter, Russel J.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
[24] Cancer metastasis: Mechanisms of inhibition by melatonin
Su, Shih-Chi
Hsieh, Ming-Ju
Yang, Wei-En
Chung, Wen-Hung
Reiter, Russel J.
Yang, Shun-Fa
JOURNAL OF PINEAL RESEARCH, 2017, 62 (01)
[25] Melatonin as a treatment for gastrointestinal cancer: a review
Xin, Zhenlong
Jiang, Shuai
Jiang, Peng
Yan, Xiaolong
Fan, Chongxi
Di, Shouyin
Wu, Guiling
Yang, Yang
Reiter, Russel J.
Ji, Gang
JOURNAL OF PINEAL RESEARCH, 2015, 58 (04) : 375 - 387
[26] Therapeutic potential of melatonin in cancer treatment
Abrial, C
Kwaitkowski, F
Chevrier, R
Gachon, F
Curé, H
Chollet, P
PATHOLOGIE BIOLOGIE, 2005, 53 (05): : 265 - 268
[27] Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
Florido, Javier
Rodriguez-Santana, Cesar
Martinez-Ruiz, Laura
Lopez-Rodriguez, Alba
Acuna-Castroviejo, Dario
Rusanova, Iryna
Escames, Germaine
ANTIOXIDANTS, 2022, 11 (08)
[28] Insights on Melatonin as an Active Pharmacological Molecule in Cancer Prevention: What's New?
Bjorklund, Geir
Rajib, Samiul Alam
Saffoon, Nadia
Pen, Joeri J.
Chirumbolo, Salvatore
CURRENT MEDICINAL CHEMISTRY, 2019, 26 (34) : 6304 - 6320
[29] Role of melatonin in carcinogenesis and metastasis: From mechanistic insights to intermeshed networks of noncoding RNAs
Lin, Xiukun
Qureshi, Muhammad Zahid
Tahir, Fatima
Yilmaz, Seher
Romero, Mirna Azalea
Attar, Rukset
Farooqi, Ammad A.
CELL BIOCHEMISTRY AND FUNCTION, 2024, 42 (04)
[30] Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells
Yu, Zhenlong
Tian, Xiangge
Peng, Yuling
Sun, Zheng
Wang, Chao
Tang, Ning
Li, Bin
Jian, Yuqing
Wang, Wei
Huo, Xiaokui
Ma, Xiaochi
JOURNAL OF PINEAL RESEARCH, 2018, 65 (01)

← 1 2 3 4 5 →