INDUCTION OF SWELLING, SYNOVIAL HYPERPLASIA AND CARTILAGE PROTEOGLYCAN LOSS UPON INTRAARTICULAR INJECTION OF TRANSFORMING GROWTH-FACTOR-BETA-2 IN THE RABBIT

被引：59

作者：

ELFORD, PR ^{[1
]}

GRAEBER, M ^{[1
]}

OHTSU, H ^{[1
]}

AEBERHARD, M ^{[1
]}

LEGENDRE, B ^{[1
]}

WISHART, WL ^{[1
]}

MACKENZIE, AR ^{[1
]}

机构：

[1] SANDOZ PRECLIN RES,DEPT BIOTECHNOL,BASEL,SWITZERLAND

来源：

CYTOKINE | 1992年 / 4卷 / 03期

关键词：

ARTHRITIS CARTILAGE INTERLEUKIN-1 SYNOVIUM TRANSFORMING GROWTH FACTOR-BETA;

D O I：

10.1016/1043-4666(92)90061-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor β (TGF-β) is a multifunctional homodimeric polypeptide with potent actions upon many target cells, including those of mesenchymal and haemopoietic lineage. The recent reports of high levels of the cytokine in rheumatoid synovium and synovial fluid, prompted this study into the effect of intra-articular injection of TGFβ-2 into rabbit knee-joints. Four daily injections of 1 μg caused swelling, probably as a consequence of prostaglandin E2 production, synovial fibroblastic hyperplasia and a striking loss of femoral condyle proteoglycan. Using the polymerase chain reaction, no evidence could be obtained for the induction of interleukin-1α gene expression in either synovial tissue or synovial fluid cells. These findings suggest that the TGF-β present in the rheumatoid joint may contribute directly to the pathogenesis of rheumatoid arthritis. © 1992.

引用

页码：232 / 238

页数：7

共 40 条

[1] RAPID ONSET SYNOVIAL INFLAMMATION AND HYPERPLASIA INDUCED BY TRANSFORMING GROWTH FACTOR-BETA [J].