GENETIC SPECIFICATION OF LIFE-SPAN AND SELF-FERTILITY IN RECOMBINANT-INBRED STRAINS OF CAENORHABDITIS-ELEGANS

被引：22

作者：

BROOKS, A ^{[1
]}

JOHNSON, TE ^{[1
]}

机构：

[1] UNIV COLORADO, DEPT PSYCHOL, BOULDER, CO 80309 USA

来源：

HEREDITY | 1991年 / 67卷

关键词：

ANTAGONISTIC PLEIOTROPY; FERTILITY; LIFE-HISTORY; LIFE SPAN; RECOMBINANT INBRED; SELECTIVE BREEDING;

D O I：

10.1038/hdy.1991.60

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

The genetic basis of life-span and age-specific fertility has been analysed using recombinant-inbred strains of the nematode Caenorhabditis elegans. Estimates of narrow-sense heritability range from 0.05 to 0.36 for life span and from 0.36 to 0.49 for total self-fertility. Positive phenotypic and genetic correlations for life span and total fertility were also observed, although in most cases the correlations were not significant. In general, age-specific hermaphrodite fertility was positively correlated with fertility on contiguous days but was negatively correlated with fertility on more distant days. We estimate that a minimum of two to three genes specify each of these traits in this genetic background. Three single-gene markers were used to generate strain distribution patterns, and two of these were found to be linked with loci that specify life span and/or fertility. We also saw evidence for a significant environmental component affecting self-fertility.

引用

页码：19 / 28

页数：10

共 39 条

[1]

[Anonymous], 1952, UNSOLVED PROBLEM BIO

[2] RECOMBINANT-INBRED STRAINS - AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES [J].