FLUVOXAMINE PIMOZIDE TREATMENT OF CONCURRENT TOURETTES AND OBSESSIVE-COMPULSIVE DISORDER

被引：67

作者：

DELGADO, PL ^{[1
]}

GOODMAN, WK ^{[1
]}

PRICE, LH ^{[1
]}

HENINGER, GR ^{[1
]}

CHARNEY, DS ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PSYCHIAT,CONNECTICUT MENTAL HLTH CTR,CLIN NEUROSCI RES UNIT,NEW HAVEN,CT 06508

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1990年 / 157卷

关键词：

D O I：

10.1192/bjp.157.5.762

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A 25-year-old man with a history of Tourette's syndrome presented for treatment of OCD symptoms. Fluvoxamine worsened tics, led to coprolalia, and did not help the OCD. The addition of pimozide dramatically reduced both OCD and Tourette's symptoms. Double-blind sequential discontinuation of fluvoxamine and pimozide confirmed that pimozide alone reduced only tics and the combination of fluvoxamine and pimozide was required for the improvement in OCD. Tics may reflect a subtype of OCD. Some OCD patients unresponsive to a 5-HT reuptake inhibitor alone may benefit from the addition of a dopamine antagonist.

引用

页码：762 / 765

页数：4

共 15 条

[1] TRIAL OF CHLORIMIPRAMINE AND DESIPRAMINE FOR GILLES-DE-LA-TOURETTE SYNDROME [J].