Exploiting conformational transitions in protein kinases for the discovery of polyvalent inhibitors

被引：0
|
作者：
da Silva, Gabriel [1 ]
Rubenstein, Brenda M. [2 ]
机构：
[1] Brown Univ, Mol & Cellular Biol & Biochem, Providence, RI 02912 USA
[2] Brown Univ, Chem, Providence, RI 02912 USA
来源：
BIOPHYSICAL JOURNAL | 2022年 / 121卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2188-Pos
引用
收藏
页码：453A / 453A
页数：1
相关论文
共 50 条
  • [1] Peptide inhibitors of protein kinases - discovery, characterisation and use
    Bogoyevitch, MA
    Barr, RK
    Ketterman, AJ
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2): : 79 - 99
  • [2] Conformational transitions and interactions underlying the function of membrane embedded receptor protein kinases
    Bocharov, Eduard V.
    Sharonov, Georgy V.
    Bocharova, Olga V.
    Pavlov, Konstantin V.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2017, 1859 (09): : 1417 - 1429
  • [3] Targeting protein kinases for bone disease: Discovery and development of Src inhibitors
    Metcalf, CA
    van Schravendijk, MR
    Dalgarno, DC
    Sawyer, TK
    CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (23) : 2049 - 2075
  • [4] The conformational plasticity of protein kinases
    Huse, M
    Kuriyan, J
    CELL, 2002, 109 (03) : 275 - 282
  • [5] Exploiting Protein Phosphatase Inhibitors Based on Cantharidin Analogues for Cancer Drug Discovery
    Deng, Liping
    Dong, Jian
    Wang, Wei
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2013, 13 (08) : 1166 - 1176
  • [6] Conformational Transitions of Histidine Kinases using Molecular Dynamics
    Idiris, Fathia
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 506A - 506A
  • [7] Exploring the conformational landscape of protein kinases
    Gough, Nancy R.
    Kalodimos, Charalampos G.
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2024, 88
  • [8] Targeting Conformational Plasticity of Protein Kinases
    Tong, Michael
    Seeliger, Markus A.
    ACS CHEMICAL BIOLOGY, 2015, 10 (01) : 190 - 200
  • [9] A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR
    Eathiraj, Sudharshan
    Palma, Rocio
    Hirschi, Marscha
    Volckova, Erika
    Nakuci, Enkeleda
    Castro, Jennifer
    Chen, Chang-Rung
    Chan, Thomas C. K.
    France, Dennis S.
    Ashwell, Mark A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (23) : 20677 - 20687
  • [10] Understanding and exploiting substrate recognition by protein kinases
    Turk, Benjamin E.
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2008, 12 (01) : 4 - 10
12345