A COMPARISON OF LSD-25 WITH (-)-DELTA9-TRANS-TETRAHYDROCANNABINOL (THC) AND ATTEMPTED CROSS TOLERANCE BETWEEN LSD AND THC

被引：79
作者：
ISBELL, H
JASINSKI, DR
机构：
[1] Departments of Medicine and Pharmacology, University of Kentucky, Medical Center, Lexington, Kentucky
[2] Department of Health, Education and Welfare, N.I.M.H. Addiction Research Center, Lexington, 40506, Kentucky
来源：
PSYCHOPHARMACOLOGIA | 1969年 / 14卷 / 02期
关键词：
(-)-Δ[!sup]9[!/sup]-TetrahydrocannabinoI; Cannabis; LSD and THC Cross-Tolerance; LSD Tolerance; Lysergic Acid Diethylamide; Marihuana;
D O I：
10.1007/BF00403684
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
1. The objective and subjective effects of 0.5 and 1.5 mcg/kg of LSD intramuscularly were compared with those of 75 and 225 mcg/kg of (-)-Δ9-trans-tetrahydrocannabinol by smoking in the same eight subjects. 2. The objective effects of LSD and THC differed markedly. LSD increased body temperature, systolic and diastolic blood pressure, lowered the threshold for the knee-jerk, and dilated the pupils. THC had none of these effects but caused more marked tachycardia than did LSD. 3. The subjective effects of the two drugs could not be readily distinguished by the methods used. Both LSD and THC are psychotomimetic drugs. 4. Patients tolerant to LSD were not cross-tolerant to THC, indicating that the mental effects of the two drugs are probably mediated by different mechanisms. © 1969 Springer-Verlag.
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页码：115 / &
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