RELATIONS BETWEEN THE GOAT MHC (GLA) AND ANTIBODY-RESPONSE TO DIPHTHERIA TOXOID, HUMAN SERUM-ALBUMIN AND TETANUS TOXOID, USING A TWIN MODEL

被引：2

作者：

EIDE, DM ^{[1
]}

NESSE, LL ^{[1
]}

LARSEN, HJ ^{[1
]}

机构：

[1] NATL VET INST, OSLO 1, NORWAY

来源：

JOURNAL OF ANIMAL BREEDING AND GENETICS | 1994年 / 111卷 / 03期

关键词：

D O I：

10.1111/j.1439-0388.1994.tb00463.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Norwegian dairy goats were tested for possible associations between the goat lymphocyte antigen system (GLA) and antibody response to the antigens diphtheria toxoid, human-serum albumin and tetanus toxoid. The serum titres to these antigens following immunization, and their GLA-specificities, were determined in 96 twin pairs. The antibody response and GLA specificity were compared between twins: twins sharing one or more GLA specificities showed a more similar primary-antibody response to diphtheria toxoid than twins with no common specificity. The main point in comparing twins is that the MHC specificity then serves as a marker for the complete haplotype, including MHC class-II genes. However, a gene substitution model that only tests the effect of the observed class-I alleles revealed that animals with GLA specificity Eu2 had a significantly higher anti-diphtheria response than Eu2-negative animals.

引用

页码：234 / 242

页数：9

共 28 条

[1] GLUTARALDEHYDE CYANURIC CHLORIDE AND TETRAAZOTIZED O-DIANISISDINE AS COUPLING REAGENTS IN PASSIVE HEMAGGLUTINATION TEST [J].