RENDERING A MEMBRANE-PROTEIN SOLUBLE IN WATER - A COMMON PACKING MOTIF IN BACTERIAL PROTEIN TOXINS

被引：114
作者：
PARKER, MW [1 ]
PATTUS, F [1 ]
机构：
[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0968-0004(93)90096-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recently determined structures of three different protein toxins by X-ray crystallography has unexpectedly revealed a common membrane-insertion domain. This domain consists of an alpha-helical bundle of between seven and ten helices, some of which are hydrophobic. The three toxins, colicin, insecticidal delta-endotoxin and diphtheria toxin are directed towards different hosts, have different killing mechanisms and bear no sequence homology. The observation of a common membrane-insertion domain has implications for the design of therapeutic agents in combating disease.
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页码：391 / 395
页数：5
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