8-CHLORODIBENZ[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-[3-[2-(FURANYLMETHYL)THIO]-1-OXOPROPYL]HYDRAZIDE (SC-51322) - A POTENT PGE(2) ANTAGONIST AND ANALGESIC

被引：57
作者：
HALLINAN, EA
STAPELFELD, A
SAVAGE, MA
REICHMAN, M
机构：
[1] Department of Chemistry Searle, Skokie, IL 60077
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期
关键词：
D O I：
10.1016/0960-894X(94)80027-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
SC-51322 is the most potent PGE(2) antagonist (pA(2) = 8.1) and analgesic (ED(50) = 0.9 mg/kg) that has been seen in this series of N-substituted dibenzoxazepines.
引用
收藏
页码：509 / 514
页数：6
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