Potent Anti-Malaria Salts, Co-Crystals and Derivatives of Aminoquinolines with Hydroxyaromatic Acids

Antimalarial activities of salts of aminoquinolines with hydroxyaromatic acids were found to be higher than the parent components. The IC50 values of the salts were in the range of 5.9-20.3 mu M against the chloroquine-resistant strain. Antimalarial actions on the parasites were found to be independent of iron chelation, inhibition of haemozoin formation, as well as independent of the anti-oxidant activity of the salts. A covalently linked amide containing compound N-(quinolin-8-yl)-2-(quinolin-8-yloxy)acetamide was identified to have potency similar to the other salts studied in the article.