Diagnosis, classification and treatment of gestational trophoblastic neoplasia

被引：30

作者：

Biscaro, Andressa ^{[1
]}

Braga, Antonio ^{[2
,3
]}

Berkowitz, Ross Stuart ^{[4
,5
]}

机构：

[1] Univ Fed Fluminense, Maternal & Child Hlth, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil

[3] Univ Fed Fluminense, Rio De Janeiro, RJ, Brazil

[4] Harvard Med Sch, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA

[5] Brigham & Womens Hosp, Harvard Med Sch, Boston, MA USA

来源：

REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA | 2015年 / 37卷 / 01期

关键词：

Gestational trophoblastic disease/diagnosis; Gestational trophoblastic disease/classification; Gestational trophoblastic disease/drug therapy; Choriocarcinoma/drug therapy;

D O I：

10.1590/SO100-720320140005198

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.

引用

页码：42 / 51

页数：10

共 52 条

[41]

Royal College of Obstetricians and Gynaecologists [Internet], 2010, MAN GEST TROPH DIS

[42] Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Seckl, M. J. ;

Sebire, N. J. ;

Fisher, R. A. ;

Golfier, F. ;

Massuger, L. ;

Sessa, C. .

ANNALS OF ONCOLOGY, 2013, 24 :39-50

[43] Gestational trophoblastic disease [J].

Seckl, Michael J. ;

Sebire, Neil J. ;

Berkowitz, Ross S. .

LANCET, 2010, 376 (9742) :717-729

[44] Uterine artery pulsatility index improves prediction of methotrexate resistance in women with gestational trophoblastic neoplasia with FIGO score 5-6 [J].

Sita-Lumsden, A. ;

Medani, H. ;

Fisher, R. ;

Harvey, R. ;

Short, D. ;

Sebire, N. ;

Savage, P. ;

Lim, A. ;

Seckl, M. J. ;

Agarwal, R. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2013, 120 (08) :1012-1015

[45] Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000-2009 [J].

Sita-Lumsden, A. ;

Short, D. ;

Lindsay, I. ;

Sebire, N. J. ;

Adjogatse, D. ;

Seckl, M. J. ;

Savage, P. M. .

BRITISH JOURNAL OF CANCER, 2012, 107 (11) :1810-1814

[46]

Dantas PRS, 2012, J REPROD MED, V57, P305

[47] Diagnosis and treatment of gestational trophoblastic disease: ACOG practice bulletin no. 53 [J].

Soper, JT ;

Mutch, DG ;

Schink, JC .

GYNECOLOGIC ONCOLOGY, 2004, 93 (03) :575-585

[48] Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases [J].

Sung, Woo Jung ;

Shin, Hyeong Chan ;

Kim, Min-Kyung ;

Kim, Mi Jin .

KOREAN JOURNAL OF PATHOLOGY, 2013, 47 (01) :67-73

[49] The outcome of patients with low risk gestational trophoblastic neoplasia treated with single agent intramuscular methotrexate and oral folinic acid [J].

Taylor, F. ;

Grew, T. ;

Everard, J. ;

Ellis, L. ;

Winter, M. C. ;

Tidy, J. ;

Hancock, B. W. ;

Coleman, R. E. .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (15) :3184-3190

[50] The curative effect of a second curettage in persistent trophoblastic disease: A retrospective cohort survey [J].

van Trommel, NE ;

Massuger, LFAG ;

Verheijen, RHM ;

Sweep, FCGJ ;

Thomas, CMG .

GYNECOLOGIC ONCOLOGY, 2005, 99 (01) :6-13

← 1 2 3 4 5 6 →