Diagnosis, classification and treatment of gestational trophoblastic neoplasia

被引：34
作者：
Biscaro, Andressa [1 ]
Braga, Antonio [2 ,3 ]
Berkowitz, Ross Stuart [4 ,5 ]
机构：
[1] Univ Fed Fluminense, Maternal & Child Hlth, Rio De Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil
[3] Univ Fed Fluminense, Rio De Janeiro, RJ, Brazil
[4] Harvard Med Sch, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA
[5] Brigham & Womens Hosp, Harvard Med Sch, Boston, MA USA
来源：
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA | 2015年 / 37卷 / 01期
关键词：
Gestational trophoblastic disease/diagnosis; Gestational trophoblastic disease/classification; Gestational trophoblastic disease/drug therapy; Choriocarcinoma/drug therapy;
D O I：
10.1590/SO100-720320140005198
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.
引用
收藏
页码：42 / 51
页数：10
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