Diagnosis, classification and treatment of gestational trophoblastic neoplasia

被引：30

作者：

Biscaro, Andressa ^{[1
]}

Braga, Antonio ^{[2
,3
]}

Berkowitz, Ross Stuart ^{[4
,5
]}

机构：

[1] Univ Fed Fluminense, Maternal & Child Hlth, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil

[3] Univ Fed Fluminense, Rio De Janeiro, RJ, Brazil

[4] Harvard Med Sch, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA

[5] Brigham & Womens Hosp, Harvard Med Sch, Boston, MA USA

来源：

REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA | 2015年 / 37卷 / 01期

关键词：

Gestational trophoblastic disease/diagnosis; Gestational trophoblastic disease/classification; Gestational trophoblastic disease/drug therapy; Choriocarcinoma/drug therapy;

D O I：

10.1590/SO100-720320140005198

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.

引用

页码：42 / 51

页数：10

共 52 条

[1] Treatment for low-risk gestational trophoblastic disease: Comparison of single-agent methotrexate, dactinomycin and combination regimens [J].

Abrao, Renato Antonio ;

de Andrade, Jurandyr Moreira ;

Tiezzi, Daniel Guimaraes ;

Cosiski Marana, Heitor Ricardo ;

Candido dos Reis, Francisco Jose ;

Clagnan, Willian Simoes .

GYNECOLOGIC ONCOLOGY, 2008, 108 (01) :149-153

[2] Uterine artery pulsatility index: a predictor of methotrexate resistance in gestational trophoblastic neoplasia [J].

Agarwal, R. ;

Harding, V. ;

Short, D. ;

Fisher, R. A. ;

Sebire, N. J. ;

Harvey, R. ;

Patel, D. ;

Savage, P. M. ;

Lim, A. K. P. ;

Seckl, M. J. .

BRITISH JOURNAL OF CANCER, 2012, 106 (06) :1089-1094

[3] Chemotherapy and human chorionic gonadotropin concentrations 6 months after uterine evacuation of molar pregnancy: a retrospective cohort study [J].

Agarwal, Roshan ;

Teoh, Suliana ;

Short, Delia ;

Harvey, Richard ;

Savage, Philip M. ;

Seckl, Michael J. .

LANCET, 2012, 379 (9811) :130-135

[4]

Alazzam M, 2012, COCHRANE DB SYST REV, V7, P7102

[5] EMA/CO for High-Risk Gestational Trophoblastic Neoplasia: Good Outcomes With Induction Low-Dose Etoposide-Cisplatin and Genetic Analysis [J].

Alifrangis, Constantine ;

Agarwal, Roshan ;

Short, Delia ;

Fisher, Rosemary A. ;

Sebire, Neil J. ;

Harvey, Richard ;

Savage, Philip M. ;

Seckl, Michael J. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (02) :280-286

[6] Radiology of gestational trophoblastic neoplasia [J].

Allen, SD ;

Lim, AK ;

Seckl, MJ ;

Blunt, DM ;

Mitchell, AW .

CLINICAL RADIOLOGY, 2006, 61 (04) :301-313

[7] Current advances in the management of gestational trophoblastic disease [J].

Berkowitz, Ross S. ;

Goldstein, Donald Peter .

GYNECOLOGIC ONCOLOGY, 2013, 128 (01) :3-5

[8] Current management of gestational trophoblastic diseases [J].

Berkowitz, Ross S. ;

Goldstein, Donald P. .

GYNECOLOGIC ONCOLOGY, 2009, 112 (03) :654-662

[9]

Braga A, 2014, J REPROD MED, V59, P241

[10] Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women [J].

Braga, Antonio ;

Maesta, Izildinha ;

Michelin, Odair Carlito ;

Gomes Delmanto, Lucia Regina ;

Consonni, Marcos ;

Cunha Rudge, Marilza Vieira ;

Belfort, Paulo .

GYNECOLOGIC ONCOLOGY, 2009, 112 (03) :568-571

← 1 2 3 4 5 6 →