Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum

被引:6
作者
Katayama, Hiroko [1 ]
Tachibana, Daisuke [1 ]
Hamuro, Akihiro [1 ]
Misugi, Takuya [1 ]
Motoyama, Koka [2 ]
Morioka, Tomoaki [2 ]
Fukumoto, Shinya [3 ]
Emoto, Masanori [2 ]
Inaba, Masaaki [2 ]
Koyama, Masayasu [1 ]
机构
[1] Osaka City Univ, Grad Sch Med, Dept Obstet & Gynecol, Abeno Ku, Osaka 558, Japan
[2] Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, Abeno Ku, Osaka 558, Japan
[3] Osaka City Univ, Dept Premier Prevent Med, Grad Sch Med, Abeno Ku, Osaka 558, Japan
来源
JAPANESE CLINICAL MEDICINE | 2015年 / 6卷
关键词
gestational diabetes mellitus; insulinogenic index; homeostasis model assessment-insulin resistance;
D O I
10.4137/JCM.S32743
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design. PATIENTS AND METHODS: Data were obtained from 85 Japanese women with GDM who delivered from April 2011 through April 2015 and who underwent an OGTT 6-14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG). We analyzed the associations between postpartum IGT-IFG and various factors. RESULTS: Antenatally, a significant difference was observed between the groups only in the 1-hour plasma glucose level of the 75-g OGTT. Postpartum results of plasma glucose level were significantly higher at 0.5, 1, and 2 hours in the IGT-IFG group than those in the NGT group. Moreover, a significant decrease in the levels of 0.5-hour immunoreactive insulin and insulinogenic index was observed in the IGT-IFG group compared to those in the NGT group. Homeostasis model assessment-insulin resistance and homeostasis model assessment beta-cell function of both groups were found to significantly decrease in the postpartum period; however, there was no significant change in the insulinogenic index of either group. CONCLUSIONS: Our study clearly showed that the postpartum IGT and IFG levels of Japanese women with GDM are affected by impaired early-phase insulin secretion; however, insulin resistance promptly improves.
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页数:5
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