Association of polymorphic variants of biotransformation system genes with a bronchial asthma in Tatars

被引：0

作者：

Fedorova, J. J. ^{[1
,2
]}

Karunas, A. S. ^{[2
]}

Gra, O. A.

Ramazanova, N. N. ^{[5
]}

Gureva, L. L. ^{[5
]}

Etkina, E., I ^{[6
]}

Goldenkova-Pavlova, I., V ^{[7
]}

Khusnutdinova, E. K. ^{[2
,3
,4
]}

机构：

[1] Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Moscow, Russia

[2] Bashkir State Med Univ, Dept Childrens Dis, Ufa, Russia

[3] Bashkir State Med Univ, Dept Childrens Dis, Biol Sci, Ufa, Russia

[4] Bashkir State Med Univ, Dept Childrens Dis, Dept Mol Genet, Ufa, Russia

[5] RAS, Inst Gen Genet NI Vavilov, Moscow, Russia

[6] RAS, Inst Gen Genet NI Vavilov, Med Sci, Moscow, Russia

[7] Grp Biochem Genet, Moscow, Russia

来源：

YAKUT MEDICAL JOURNAL | 2009年 / 02期

关键词：

bronchial asthma; polymorpHism; association; oligonucleotide biochips; xenobiotic-metabolizing genes;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Using allele-specific hybridization on the biochip the frequencies of xenobiotic-metabolizing gene polymorpHisms (CYP1A1, CYP2D6, GSTT1, GSTM1, MTHFR, CYP2C9, CYP2C19. NAT2) in patients with bronchial asthma and controls of Tatar ethnicity have been determined. It has been shown that NAT2*481T/T genotype and NAT2*481T, MTHFR*677C alleles are markers of asthma risk.

引用

页码：93 / 95

页数：3

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