HIGH-YIELD SYNTHESIS OF HIGH-PURITY [F-18] LABELED AROMATIC-COMPOUNDS BY ARYL F-FOR-X HALOGEN EXCHANGE-REACTIONS

被引：7
作者：
HASHIZUME, K
HASHIMOTO, N
CORK, DG
MIYAKE, Y
机构：
来源：
CHEMISTRY LETTERS | 1995年 / 09期
关键词：
D O I：
10.1246/cl.1995.835
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The relative efficacy of aromatic fluorine-for-halogen (F-X) exchange reactions was found to be F-F > F-Cl > F-Br > F-I in a [F-18]fluoride-cryptand-oxalate system using 4'-haloacetophenones (F, Cl, Br and I), key intermediates for many F-18-radiopharmaceuticals. Efficient F-18-labelling reaction and a new chromatographic separation method has enabled the potential of F-for-X exchange (X=Cl and F) to be realized for the high yield synthesis of high purity [F-18]-neuroleptics.
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页码：835 / 836
页数：2
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