The neutrophil-to-lymphocyte ratio: a narrative review

被引：264

作者：

Faria, Sara Socorro ^{[1
]}

Fernandes, Paulo Cesar, Jr. ^{[2
]}

Barbosa Silva, Marcelo Jose ^{[2
]}

Lima, Vladmir C. ^{[2
]}

Fontes, Wagner ^{[3
]}

Freitas-Junior, Ruffo ^{[4
]}

Eterovic, Agda Karina ^{[5
]}

Forget, Patrice ^{[6
]}

机构：

[1] Fed Univ Uberlandia UFU, Mastol Program, Ave Engenheiro Diniz 1178,Reitoria 3 Andar, Uberlandia, MG, Brazil

[2] AC Camargo Canc Ctr, Dept Med Oncol, R Prof Antonio Prudente 211, BR-01509 Liberdade, SP, Brazil

[3] Univ Brasilia UnB, Lab Biochem Prot Chem Prote Res, Campus Univ Darcy Ribeiro S-N Asa Norte, BR-70910900 Brasilia, DF, Brazil

[4] Fed Univ Goias UFG, Mastol Program, Rodovia Goiania Neropolis Km 12, BR-74001970 Goiania, Go, Brazil

[5] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[6] Univ Ziekenhuis Brussel, Dept Anesthesiol & Perioperat Med, Iaarbeeklaan 101, B-1090 Brussels, Belgium

来源：

ECANCERMEDICALSCIENCE | 2016年 / 10卷

关键词：

breast cancer; inflammation; neutrophil-to-lymphocyte ratio; prognosis;

D O I：

10.3332/ecancer.2016.702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.

引用

页数：12

共 48 条

[1] Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer [J].