ORIGIN OF URINARY FIBRIN-FIBRINOGEN DEGRADATION PRODUCTS IN RENAL GLOMERULAR-DISEASE

被引：22

作者：

HALL, CL ^{[1
]}

BLAINEY, JD ^{[1
]}

GAFFNEY, PJ ^{[1
]}

机构：

[1] NATL INST BIOL STAND & CONTROL, LONDON NW3 6RB, ENGLAND

来源：

NEPHRON | 1979年 / 23卷 / 01期

关键词：

D O I：

10.1159/000181598

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The origin and mechanism of renal clearance of urinary 'fibrin-fibrinogen degradation products' (FDP) were studied in patients with renal glomerular diseases associated with heavy, non-selective proteinuria and high levels of urinary FDP. The results indicated that the urinary FDP arose primarily by the filtration of unaltered plasma fibrinogen through a damaged and abnormally permeable glomerular basement membrane and that a variable degree of lysis of the filtered fibrinogen occurred in the urine. The lysis of cross-linked fibrin in intraglomerular deposits, as evidenced by the presence of dimeric fragment D in the urine, appeared to contribute only a small amount to the total urinary FDP excretion.

引用

页码：6 / 9

页数：4

共 17 条

[1]

CLARKE HGM, 1968, CLIN SCI, V35, P403

[2] SERUM AND URINARY FIBRIN/FIBRINOGEN DEGRADATION PRODUCTS IN GLOMERULONEPHRITIS [J].

CLARKSON, AR ;

MACDONALD, MK ;

PETRIE, JJB ;

CASH, JD ;

ROBSON, JS .

BMJ-BRITISH MEDICAL JOURNAL, 1971, 3 (5772) :447-+

[3]

CORTES P, 1973, J LAB CLIN MED, V82, P377

[4] ORIGIN OF URINARY FIBRIN-FIBRINOGEN DEGRADATION PRODUCTS IN GLOMERULONEPHRITIS [J].

EKBERG, M ;

PANDOLFI, M .

BRITISH MEDICAL JOURNAL, 1975, 2 (5961) :17-19

[5] IMMUNOLOGICALLY REACTIVE EQUIVALENTS OF FIBRINOGEN IN SERA AND URINE OF CHILDREN WITH RENAL-DISEASE [J].

EKERT, H ;

BARRATT, TM ;

CHANTLER, C ;

TURNER, MW .

ARCHIVES OF DISEASE IN CHILDHOOD, 1972, 47 (251) :90-+

[6] PLASMA FIBRINOGEN AND ITS FRAGMENTS DURING STREPTOKINASE TREATMENT [J].

GAFFNEY, PJ ;

CHESTERMAN, CN ;

ALLINGTON, MJ .

BRITISH JOURNAL OF HAEMATOLOGY, 1974, 26 (02) :285-+

[7] FIBRIN SUBUNITS IN VENOUS AND ARTERIAL THROMBOEMBOLISM [J].

GAFFNEY, PJ ;

BRASHER, M ;

LORD, K ;

STRACHAN, CJL ;

WILKINSON, AR ;

KAKKAR, VV ;

SCULLY, MF .

CARDIOVASCULAR RESEARCH, 1976, 10 (04) :421-426

[8] SOLUBLE HIGH-MOLECULAR-WEIGHT E-FRAGMENTS IN PLASMIN-INDUCED DEGRADATION PRODUCTS OF CROSS-LINKED HUMAN FIBRIN [J].

GAFFNEY, PJ ;

LANE, DA ;

BRASHER, M .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1975, 49 (02) :149-156

[9] DISTINCTION BETWEEN FIBRINOGEN AND FIBRIN DEGRADATION PRODUCTS IN PLASMA [J].

GAFFNEY, PJ .

CLINICA CHIMICA ACTA, 1975, 65 (01) :109-115

[10] URINARY FIBRIN-FIBRINOGEN DEGRADATION PRODUCTS IN NEPHROTIC SYNDROME [J].

HALL, CL ;

PEJHAN, N ;

TERRY, JM ;

BLAINEY, JD .

BRITISH MEDICAL JOURNAL, 1975, 1 (5955) :419-422

← 1 2 →