A NOVEL GENE DELIVERY SYSTEM USING EGF RECEPTOR-MEDIATED ENDOCYTOSIS

被引：100
|
作者：
CHEN, JB [1 ]
GAMOU, S [1 ]
TAKAYANAGI, A [1 ]
SHIMIZU, N [1 ]
机构：
[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,SHINJUKU KU,TOKYO 160,JAPAN
来源：
FEBS LETTERS | 1994年 / 338卷 / 02期
关键词：
EGF RECEPTOR; ENDOCYTOSIS; MONOCLONAL ANTIBODY; GENE THERAPY;
D O I：
10.1016/0014-5793(94)80357-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.
引用
收藏
页码：167 / 169
页数：3
相关论文
共 50 条
  • [41] Receptor-Mediated Endocytosis across Human Placenta: Emphasis on Megalin
    Akour, Amal A.
    Kennedy, Mary Jayne
    Gerk, Phillip
    MOLECULAR PHARMACEUTICS, 2013, 10 (04) : 1269 - 1278
  • [42] Receptor-mediated delivery of foreign genes to hepatocytes
    Wu, GY
    Wu, CH
    ADVANCED DRUG DELIVERY REVIEWS, 1998, 29 (03) : 243 - 248
  • [43] Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
    Ritchie, Michael
    Tchistiakova, Lioudmila
    Scott, Nathan
    MABS, 2013, 5 (01) : 13 - 21
  • [44] Receptor-mediated targeted drug or toxin delivery
    Ríhova, B
    ADVANCED DRUG DELIVERY REVIEWS, 1998, 29 (03) : 273 - 289
  • [45] Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets
    Paul, Manoj
    Hong, Felix
    Falet, Herve
    Kim, Hugh
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2024, 22 (09) : 2601 - 2607
  • [46] Receptor-mediated endocytosis and intracellular trafficking of lipoproteins and transferrin in insect cells
    Van Hoof, D
    Rodenburg, KW
    Van der Horst, DJ
    INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2005, 35 (02) : 117 - 128
  • [47] Receptor-mediated endocytosis of poly(acrylic acid)-conjugated liposomes by macrophages
    Fujiwara, M
    Baldeschwieler, JD
    Grubbs, RH
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1996, 1278 (01): : 59 - 67
  • [48] Role of physicochemical properties of coating ligands in receptor-mediated endocytosis of nanoparticles
    Ding, Hong-ming
    Ma, Yu-qiang
    BIOMATERIALS, 2012, 33 (23) : 5798 - 5802
  • [49] Role of Rab5 in insulin receptor-mediated endocytosis and signaling
    Hunker, C. M.
    Hunker, I.
    Kruk, I.
    Hall, J.
    Giambini, H.
    Veisaga, M. L.
    Barbieri, M. A.
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 449 (1-2) : 130 - 142
  • [50] A Differential Role for Endocytosis in Receptor-Mediated Activation of Nox1
    Miller, Francis J., Jr.
    Chu, Xi
    Stanic, Bojana
    Tian, Xin
    Sharma, Ram V.
    Davisson, Robin L.
    Lamb, Fred S.
    ANTIOXIDANTS & REDOX SIGNALING, 2010, 12 (05) : 583 - 593
12345