A NOVEL GENE DELIVERY SYSTEM USING EGF RECEPTOR-MEDIATED ENDOCYTOSIS

被引：100
|
作者：
CHEN, JB [1 ]
GAMOU, S [1 ]
TAKAYANAGI, A [1 ]
SHIMIZU, N [1 ]
机构：
[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,SHINJUKU KU,TOKYO 160,JAPAN
来源：
FEBS LETTERS | 1994年 / 338卷 / 02期
关键词：
EGF RECEPTOR; ENDOCYTOSIS; MONOCLONAL ANTIBODY; GENE THERAPY;
D O I：
10.1016/0014-5793(94)80357-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.
引用
收藏
页码：167 / 169
页数：3
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