A NOVEL GENE DELIVERY SYSTEM USING EGF RECEPTOR-MEDIATED ENDOCYTOSIS

被引：100
|
作者：
CHEN, JB [1 ]
GAMOU, S [1 ]
TAKAYANAGI, A [1 ]
SHIMIZU, N [1 ]
机构：
[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,SHINJUKU KU,TOKYO 160,JAPAN
来源：
FEBS LETTERS | 1994年 / 338卷 / 02期
关键词：
EGF RECEPTOR; ENDOCYTOSIS; MONOCLONAL ANTIBODY; GENE THERAPY;
D O I：
10.1016/0014-5793(94)80357-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.
引用
收藏
页码：167 / 169
页数：3
相关论文
共 50 条
  • [1] Hepatocyte-directed gene delivery by receptor-mediated endocytosis
    Smith, RM
    Wu, GY
    SEMINARS IN LIVER DISEASE, 1999, 19 (01) : 83 - 92
  • [2] Strategies to accomplish gene delivery via the receptor-mediated endocytosis pathway
    Cristiano, RJ
    Curiel, DT
    CANCER GENE THERAPY, 1996, 3 (01) : 49 - 68
  • [3] RECEPTOR-MEDIATED ENDOCYTOSIS AND TARGETED DRUG DELIVERY
    FALLON, RJ
    SCHWARTZ, AL
    HEPATOLOGY, 1985, 5 (05) : 899 - 901
  • [4] Construction of an EGF receptor-mediated histone H10-based gene delivery system
    Dai, FH
    Chen, Y
    Ren, CC
    Li, JJ
    Yao, M
    Han, JS
    Gong, Y
    Yang, SL
    Zhu, JD
    Gu, JR
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2003, 129 (08) : 456 - 462
  • [5] Construction of an EGF receptor-mediated histone H10-based gene delivery system
    Fei-Han Dai
    Yan Chen
    Chang-Chun Ren
    Jin-Jun Li
    Min Yao
    Jun-Song Han
    Yi Gong
    Sheng-Li Yang
    Jing-De Zhu
    Jian-Ren Gu
    Journal of Cancer Research and Clinical Oncology, 2003, 129 : 456 - 462
  • [6] THE EGF RECEPTOR-MEDIATED GENE DELIVERY - IMMUNOGENE APPROACH TO CANCER GENE-THERAPY
    SHIMIZU, N
    CHEN, J
    GAMOU, S
    TAKAYANAGI, A
    AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 220 - 220
  • [7] TARGETED GENE DELIVERY TO ALVEOLAR MACROPHAGES VIA FC RECEPTOR-MEDIATED ENDOCYTOSIS
    ROJANASAKUL, Y
    WANG, LY
    MALANGA, CJ
    MA, JKH
    LIAW, JH
    PHARMACEUTICAL RESEARCH, 1994, 11 (12) : 1731 - 1736
  • [8] STRATEGIES TO ACHIEVE TARGETED GENE DELIVERY VIA THE RECEPTOR-MEDIATED ENDOCYTOSIS PATHWAY
    MICHAEL, SI
    CURIEL, DT
    GENE THERAPY, 1994, 1 (04) : 223 - 232
  • [9] RECEPTOR-MEDIATED GENE DELIVERY
    COTTEN, M
    WAGNER, E
    ZATLOUKAL, K
    BUSCHLE, M
    CHIOCCA, S
    PLANK, C
    ZAUNER, W
    SCHMIDT, W
    BIRNSTIEL, ML
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 214 - 214
  • [10] LATERAL AND ROTATIONAL DIFFUSION OF EGF RECEPTOR COMPLEX - RELATIONSHIP TO RECEPTOR-MEDIATED ENDOCYTOSIS
    SCHLESSINGER, J
    BIOPOLYMERS, 1983, 22 (01) : 347 - 353
12345