A NOVEL GENE DELIVERY SYSTEM USING EGF RECEPTOR-MEDIATED ENDOCYTOSIS

被引：100

作者：

CHEN, JB ^{[1
]}

GAMOU, S ^{[1
]}

TAKAYANAGI, A ^{[1
]}

SHIMIZU, N ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,SHINJUKU KU,TOKYO 160,JAPAN

来源：

FEBS LETTERS | 1994年 / 338卷 / 02期

关键词：

EGF RECEPTOR; ENDOCYTOSIS; MONOCLONAL ANTIBODY; GENE THERAPY;

D O I：

10.1016/0014-5793(94)80357-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

引用

页码：167 / 169

页数：3

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