SLEEP-DEPRIVATION ACCELERATES THE RESPONSE TO NORTRIPTYLINE

被引：29
|
作者：
SHELTON, RC
LOOSEN, PT
机构：
[1] DEPT VET AFFAIRS MED CTR,NASHVILLE,TN
[2] VANDERBILT UNIV,SCH MED,DEPT PHARMACOL,NASHVILLE,TN 37212
[3] VANDERBILT UNIV,SCH MED,DEPT MED,NASHVILLE,TN 37212
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1993年 / 17卷 / 01期
关键词：
ANTIDEPRESSANTS; DEPRESSION; NORTRIPTYLINE; SLEEP DEPRIVATION;
D O I：
10.1016/0278-5846(93)90036-R
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. The authors examined the effect of total sleep deprivation (SD) in combination with nortriptyline in 20 patients with major depressive disorder (MDD). Patients underwent a 36-hour SD procedure followed by nortriptyline started on the evening after SD, with ratings for two weeks. 2. Eleven (55%) patients were responders; they showed a rapid and sustained remission after SD, whereas non-responders demonstrated the delayed results expected with nortriptyline. 3. High initial depression scores and absence of depersonalization were associated with response to SD, while being female and middle insomnia were associated with response to the combined regimen. 4. The combination of SD with antidepressants proves to be an effective and safe treatment modality.
引用
收藏
页码：113 / 123
页数：11
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