INHIBITION BY CATECHOL AND DI(2-ETHYLHEXYL)PHTHALATE OF PANCREATIC CARCINOGENESIS AFTER INITIATION WITH N-NITROSOBIS(2-HYDROXYPROPYL)AMINE IN SYRIAN-HAMSTERS

被引：5

作者：

MARUYAMA, H

AMANUMA, T

TSUTSUMI, M

TSUJIUCHI, T

HORIGUCHI, K

DENDA, A

KONISHI, Y

机构：

[1] Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Nara 634

来源：

CARCINOGENESIS | 1994年 / 15卷 / 06期

关键词：

D O I：

10.1093/carcin/15.6.1193

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of dietary administration of catechol (CC), paramethylcatechol (PMC) and di(2-ethylhexyl)phthalate (DEHP) were compared with that of butylated hydroxyanisole (BHA) in Syrian hamsters initiated with N-nitrosobis(2-hydroxypropyl)amine (BHP). Development of pancreatic atypical hyperplasias and adenocarcinomas in terms of combined multiplicity was significantly reduced by CC and DEHP. A similar slight but non-significant tendency was observed for BHA, while PMC was without effect. No statistically significant reduction of liver or gall bladder lesions was observed. The results thus suggest that both antioxidant and peroxisome proliferator categories of agents can inhibit pancreatic carcinogenesis in hamsters.

引用

页码：1193 / 1196

页数：4

共 20 条

[1] POSSIBLE TUMOR-INITIATING AND TUMOR-PROMOTING ACTIVITY OF P-METHYLCATECHOL AND METHYLHYDROQUINONE IN THE PYLORIC MUCOSA OF RAT STOMACH [J].