ON THE MUTAGENICITY OF MX COMPOUNDS

被引：17
作者：
TUPPURAINEN, K
LOTJONEN, S
机构：
[1] Kuopio University NMR Research Group, Department of Chemistry, University of Kuopio
来源：
MUTATION RESEARCH | 1993年 / 287卷 / 02期
关键词：
QSAR; FRONTIER ORBITALS; HYDROPHOBICITY; MX COMPOUNDS; GUANINE;
D O I：
10.1016/0027-5107(93)90016-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Electronic properties of chlorofuranones including MX, one of the strongest bacterial mutagens, were studied using the semi-empirical AM1 method to elucidate the key features related to the high mutagenic activity of MX. The electronic structures of MX and guanine (the target base of the Salmonella typhimurium TA100 tester strain) are rationalized with the frontier electron theory. Hydrophobic properties of the MX family are examined. Based on these results and our previous QSAR model a possible mechanism for the MX-DNA interaction is proposed.
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页码：235 / 241
页数：7
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