CHARACTERIZATION OF AEROALLERGEN-INDUCED DYSPNEA IN UNRESTRAINED GUINEA-PIGS BY BIAS-FLOW-VENTILATED WHOLE-BODY PLETHYSMOGRAPHY

被引：6

作者：

CHAND, N ^{[1
]}

NOLAN, K ^{[1
]}

PILLAR, J ^{[1
]}

ZOMASK, M ^{[1
]}

DIAMANTIS, W ^{[1
]}

SOFIA, RD ^{[1
]}

机构：

[1] BUXCO ELECTR INC,SHARON,CT 06069

来源：

AGENTS AND ACTIONS | 1992年 / 37卷 / 3-4期

关键词：

D O I：

10.1007/BF02028104

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pressure signal to drop from its peak to 1/3 of its peak value). All of these lung dysfunction changes were highly significant (P < 0.001). Pyrilamine (I mg/kg, p.o., - 2 h) inhibited dyspnea (DELTAP and DELTAF) by 50-53%. This technique allows quantitative analysis of allergic dyspnea in conscious, unrestrained guinea pigs.

引用

页码：184 / 187

页数：4

共 4 条

[1]

AGRAWAL KP, 1977, INDIAN J CHEST DIS, V19, P3

[2] WHOLE-BODY PLETHYSMOGRAPHY IN SEDENTARY OR EXERCISE CONDITIONS TO DETERMINE PULMONARY TOXICITY, INCLUDING HYPERSENSITIVITY INDUCED BY AIRBORNE TOXICANTS [J].