EFFECTS OF CONCURRENT NICOTINIC ANTAGONIST AND PCPA TREATMENTS ON SPATIAL AND PASSIVE-AVOIDANCE LEARNING

被引：30
作者：
RIEKKINEN, P
RIEKKINEN, M
SIRVIO, J
RIEKKINEN, P
机构：
[1] Department of Neurology, University of Kuopio, Kuopio
来源：
BRAIN RESEARCH | 1992年 / 575卷 / 02期
关键词：
NICOTINIC CHOLINERGIC RECEPTOR; MECAMYLAMINE; SEROTONIN; PARA-CHLOROPHENYLALANINE; LEARNING PERFORMANCE; ALZHEIMERS DISEASE;
D O I：
10.1016/0006-8993(92)90086-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study investigates the effects of concurrent manipulations of nicotinic cholinergic receptors (mecamylamine 10 mg/kg, i.p.) and serotonin neurons (PCPA, 400 mg on each of 4 days) on spatial navigation (water maze, WM) and passive avoidance (PA) performance. PCPA treatment had no effect on WM navigation or PA performance of intact rats, but greatly aggravated mecamylamine induced performance deficit. Either single or combined treatments with hexamethonium (5.0 mg/kg, s.c.) and PCPA had no effect on WM or PA performance. These findings may suggest that nicotinic cholinergic receptors are are also importantly involved in the cholinergic-serotonergic regulation of cognitive functioning.
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收藏
页码：247 / 250
页数：4
相关论文
共 25 条
[1]   BIOCHEMICAL-EVIDENCE OF SELECTIVE NERVE-CELL CHANGES IN THE NORMAL AGING HUMAN AND RAT-BRAIN [J].
ALLEN, SJ ;
BENTON, JS ;
GOODHARDT, MJ ;
HAAN, EA ;
SIMS, NR ;
SMITH, CCT ;
SPILLANE, JA ;
BOWEN, DM ;
DAVISON, AN .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (01) :256-265
[2]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[3]   BIOCHEMICAL ASSESSMENT OF SEROTONERGIC AND CHOLINERGIC DYSFUNCTION AND CEREBRAL ATROPHY IN ALZHEIMERS-DISEASE [J].
BOWEN, DM ;
ALLEN, SJ ;
BENTON, JS ;
GOODHARDT, MJ ;
HAAN, EA ;
PALMER, AM ;
SIMS, NR ;
SMITH, CCT ;
SPILLANE, JA ;
ESIRI, MM ;
NEARY, D ;
SNOWDON, JS ;
WILCOCK, GK ;
DAVISON, AN .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (01) :266-272
[4]   DEGENERATIVE CHANGES IN FOREBRAIN CHOLINERGIC NUCLEI CORRELATE WITH COGNITIVE IMPAIRMENTS IN AGED RATS [J].
FISCHER, W ;
GAGE, FH ;
BJORKLUND, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1989, 1 (01) :34-45
[5]   AFFERENTS TO THE BASAL FOREBRAIN CHOLINERGIC CELL AREA FROM PONTOMESENCEPHALIC CATECHOLAMINE, SEROTONIN, AND ACETYLCHOLINE NEURONS [J].
JONES, BE ;
CUELLO, AC .
NEUROSCIENCE, 1989, 31 (01) :37-61
[6]   CORTICAL PROJECTION PATTERNS OF MAGNOCELLULAR BASAL NUCLEUS SUBDIVISIONS AS REVEALED BY ANTEROGRADELY TRANSPORTED PHASEOLUS-VULGARIS LEUKOAGGLUTININ [J].
LUITEN, PGM ;
GAYKEMA, RPA ;
TRABER, J ;
SPENCER, DG .
BRAIN RESEARCH, 1987, 413 (02) :229-250
[7]   APPLICATION OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION TO NEUROCHEMICAL ANALYSIS - MEASUREMENT OF CATECHOLAMINES, SEROTONIN AND METABOLITES IN RAT-BRAIN [J].
MEFFORD, IN .
JOURNAL OF NEUROSCIENCE METHODS, 1981, 3 (03) :207-224
[8]   COMBINED CHOLINERGIC AND SEROTONERGIC DENERVATION OF THE FOREBRAIN PRODUCES SEVERE DEFICITS IN A SPATIAL-LEARNING TASK IN THE RAT [J].
NILSSON, OG ;
STRECKER, RE ;
DASZUTA, A ;
BJORKLUND, A .
BRAIN RESEARCH, 1988, 453 (1-2) :235-246
[9]   CHANGES IN MONAMINES AND THEIR METABOLITE LEVELS IN SOME BRAIN-REGIONS OF AGED RATS [J].
PONZIO, F ;
CALDERINI, G ;
LOMUSCIO, G ;
VANTINI, G ;
TOFFANO, G ;
ALGERI, S .
NEUROBIOLOGY OF AGING, 1982, 3 (01) :23-29
[10]   CHOLINERGIC DEFICIT IN ALZHEIMERS-DISEASE - A STUDY BASED ON CSF AND AUTOPSY DATA [J].
REINIKAINEN, KJ ;
RIEKKINEN, PJ ;
PALJARVI, L ;
SOININEN, H ;
HELKALA, EL ;
JOLKKONEN, J ;
LAAKSO, M .
NEUROCHEMICAL RESEARCH, 1988, 13 (02) :135-146
123