AMPHOTERICIN-B O-METHYL OXIME - SYNTHESIS AND BIOLOGICAL PROPERTIES

被引:6
作者
CZERWINSKI, A
KONIG, WA
SOWINSKI, P
FALKOWSKI, L
MAZERSKI, J
BOROWSKI, E
机构
[1] UNIV HAMBURG,INST ORGAN CHEM,W-2000 HAMBURG 13,GERMANY
[2] POLISH ACAD SCI,INST OCEANOL,PL-81967 SOPOT,POLAND
关键词
D O I
10.7164/antibiotics.43.1098
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:1098 / 1100
页数:3
相关论文
共 13 条
  • [1] COMPARATIVE CONFORMATIONAL-ANALYSIS OF CHOLESTEROL AND ERGOSTEROL BY MOLECULAR MECHANICS
    BAGINSKI, M
    TEMPCZYK, A
    BOROWSKI, E
    [J]. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1989, 17 (03): : 159 - 166
  • [2] BOROWSKI E, 1971, TETRAHEDRON LETT, P1987
  • [3] THE PROTON MAGNETIC-RESONANCE SPECTRUM OF AMPHOTERICIN-B
    BROWN, JM
    SIDEBOTTOM, PJ
    [J]. TETRAHEDRON, 1981, 37 (07) : 1421 - 1428
  • [4] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS IN AMPHOTERICIN-B DERIVATIVES
    CHERON, M
    CYBULSKA, B
    MAZERSKI, J
    GRZYBOWSKA, J
    CZERWINSKI, A
    BOROWSKI, E
    [J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) : 827 - 836
  • [5] AMIDES OF POLYENE MACROLIDE AUREOFACIN SYNTHESIS AND BIOLOGICAL PROPERTIES
    CZERWINSKI, A
    KONIG, WA
    SOWINSKI, P
    BOROWSKI, E
    [J]. JOURNAL OF ANTIBIOTICS, 1987, 40 (07) : 1023 - 1027
  • [6] THE STRUCTURE OF MEPARTRICIN-A AND MEPARTRICIN-B
    GOLIK, J
    ZIELINSKI, J
    BOROWSKI, E
    [J]. JOURNAL OF ANTIBIOTICS, 1980, 33 (08) : 904 - 906
  • [7] THE ROLE OF THE CARBOXYL AND AMINO-GROUPS OF POLYENE MACROLIDES IN THEIR INTERACTIONS WITH STEROLS AND THEIR SELECTIVE TOXICITY - A P-31-NMR STUDY
    HERVE, M
    DEBOUZY, JC
    BOROWSKI, E
    CYBULSKA, B
    GARYBOBO, CM
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 980 (03) : 261 - 272
  • [8] KOMORI T, 1989, TETRAHEDRON LETT, V30, P3813
  • [9] MECHLINSKI W, 1970, TETRAHEDRON LETT, P3873
  • [10] POLYENE ANTIBIOTICS .7. C-13 NUCLEAR MAGNETIC-RESONANCE EVIDENCE FOR CYCLIC HEMIKETALS IN POLYENE ANTIBIOTICS AMPHOTERICIN-B, NYSTATIN-A1, TETRIN-A, TETRIN-B, LUCENSOMYCIN, AND PIMARICIN
    PANDEY, RC
    RINEHART, KL
    [J]. JOURNAL OF ANTIBIOTICS, 1976, 29 (10) : 1035 - 1042