INHIBITION OF PROLYL ENDOPEPTIDASE BY SYNTHETIC PEPTIDE-FRAGMENTS OF HUMAN BETA-CASEIN

被引：26

作者：

ASANO, M

NIO, N

ARIYOSHI, Y

机构：

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1991年 / 55卷 / 03期

关键词：

D O I：

10.1080/00021369.1991.10870663

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

It has been suggested that peptide inhibitors of prolyl endopeptidase (PEP) may act as anti-amnestic agents. In the hope of finding PEP inhibitors in milk proteins, we synthesized a total of 37 human beta-casein peptide fragments containing proline residues. It was found that the peptides with PEP inhibition activity in vitro were located in the region of amino acid residues 49-59 of human beta-casein. The most potent inhibitor was Ile-Tyr-Pro-Phe-Val-Glu-Pro-Ile (IC50 = 8-mu-M).

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页码：825 / 828

页数：4

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