HUMAN CHRONIC LYMPHOCYTIC-LEUKEMIA - KARYOTYPES IN DIFFERENT LYMPHOCYTE POPULATIONS

被引：69
作者：
AUTIO, K
TURUNEN, O
PENTTILA, O
ERAMAA, E
DELACHAPELLE, A
SCHRODER, J
机构：
[1] MARIA HOSP,DEPT MED,HELSINKI,FINLAND
[2] UNIV HELSINKI,DEPT MED GENET,SF-00290 HELSINKI 29,FINLAND
来源：
CANCER GENETICS AND CYTOGENETICS | 1979年 / 1卷 / 02期
关键词：
D O I：
10.1016/0165-4608(79)90020-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Karyotypes of different lymphocyte populations from 10 patients with chronic lymphocytic leukemia (CLL) showed two types of chromosome abnormalities. In cultures containing mitogens for T cells (leukoagglutinin (LA)) as well as T and B cells (pokeweed mitogen (PWM); protein A (PA)) random structural aberrations or trisomies were seen. However, one patient had a clone with trisomy 12 in LA- as well as PA-cultured cells. This clone represented about 10-20% of all mitoses, and was observed over a time period of 4 years. Nonrandom rearrangements were found in lipopolysaccharide B (LPS)-stimulated B lymphocytes from one individual in 11 cells analyzed. All these cells had multiple chromosome rearrangements. The cells probably represented a clone, since the karyotype was almost identical in all 11 cells, and the following reciprocal translocations could be identified: t(6;7), t(7;13), and t(11;14). © 1979.
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页码：147 / 155
页数：9
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