THE PHOTO-EPIMERIZATION OF GOSSYPOL SCHIFFS BASES

被引：34
作者：
FISH, RG
GROUNDWATER, PW
MORGAN, JJG
机构：
[1] UNIV WALES COLL CARDIFF,DEPT CHEM,CARDIFF CF1 3TB,S GLAM,WALES
[2] VELINDRE HOSP,CLIN ONCOL SERV,RES LABS,CARDIFF CF1 7XL,S GLAM,WALES
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 04期
关键词：
D O I：
10.1016/0957-4166(95)00093-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
H-1 NMR studies show that the diastereoisomeric adducts 3 of gossypol 1 and (L)-phenylalanine methyl ester undergo epimerisation, in hexane/ethyl acetate or deuteriochloroform, in sunlight. The individual diastereoisomers 3 can be equilibrated to a 50:50 mixture of diastereoisomers, thus allowing an efficient procedure for the recycling of the biologically-inactive D-gossypol.
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页码：873 / 876
页数：4
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