NEW CYCLOHEXYL-BASED CHIRAL AUXILIARIES - ENANTIOSELECTIVE SYNTHESIS OF ALPHA-HYDROXY ACIDS

被引：25
作者：
BASAVAIAH, D
KRISHNA, PR
机构：
[1] School of Chemistry, University of Hyderabad, Hyderabad
来源：
TETRAHEDRON | 1995年 / 51卷 / 44期
关键词：
D O I：
10.1016/0040-4020(95)00771-Y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(1R, 2R)-2-(4-tert-Butylphenoxy) cyclohexan-1-ol (5) and (1R, 2R)-2-(4-phenylphenoxy) cyclohexan-1-ol (6) have been used for the first time as chiral auxiliaries. Addition of alkylzinc chlorides to the corresponding glyoxylates 5a, 6a, after hydrolysis, provided (R)-alpha-hydroxy acids in high optical purities.
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页码：12169 / 12178
页数：10
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