DOSE-DEPENDENT RESPONSES TO MACROPHAGE-TARGETED GLUCOCEREBROSIDASE IN A CHILD WITH GAUCHER DISEASE

被引：55

作者：

BARTON, NW

BRADY, RO

DAMBROSIA, JM

DOPPELT, SH

HILL, SC

HOLDER, CA

MANKIN, HJ

MURRAY, GJ

ZIRZOW, GC

PARKER, RI

机构：

[1] NINCDS, BIOMETRY & FIELD STUDIES BRANCH, BETHESDA, MD 20892 USA

[2] NIH, DEPT DIAGNOST RADIOL, BETHESDA, MD 20892 USA

[3] NIH, CTR CLIN, DEPT CLIN PATHOL, BETHESDA, MD 20892 USA

[4] MASSACHUSETTS GEN HOSP, DEPT ORTHOPED SURG, BOSTON, MA 02114 USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 120卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(05)80444-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Long-term studies of a child with Gaucher disease indicated that the response to treatment with macrophage-targeted glucocerebrosidase (glucosylceramidase) is dose dependent, and that the hematologic response precedes the skeletal response.

引用

页码：277 / 280

页数：4

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