BIOCHEMICAL AND GENETIC-CHARACTERIZATION OF ESTERASE-27 (ES-27), THE MAJOR PLASMA CHOLINESTERASE OF THE HOUSE MOUSE (MUS-MUSCULUS)

被引：3

作者：

VONDEIMLING, OH

GAA, A

机构：

[1] Pathologisches Institut, Abteilung für Chemische Pathologie, Universtität Freiburg, D-7800 Freiburg i. Br., Deutschland, Bundesrepublik

来源：

GENETICAL RESEARCH | 1991年 / 57卷 / 01期

关键词：

D O I：

10.1017/S0016672300029050

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100-mu-M tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere-Car-2-Es-26-Es-27-Amy-1-Adh-1.

引用

页码：61 / 70

页数：10

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